Printer Friendly
Dictionary, Encyclopedia and Thesaurus - The Free Dictionary
5,440,929,676 visitors served.

endometrial hyperplasia
(redirected from Hyperplasia with atypia)

   Also found in: Wikipedia 0.01 sec.
endometrial hyperplasia,
an abnormal condition characterized by overgrowth of the endometrium resulting from sustained stimulation by estrogen (of endogenous or exogenous origin) that is not opposed by progesterone. Estrogen acts as a growth hormone for the endometrium. Through a complex intercellular mechanism, endometrial cells bind estrogen preferentially and undergo changes characteristic of the proliferative phase of the menstrual cycle. If estrogen stimulation continues for 3 to 6 months without periodic cessation or counteractive progesterone stimulation, as occurs in anovulatory or perimenopausal women and in those receiving replacement estrogen without added progestogen, the endometrium becomes abnormally thickened and glandularized. Unremitting estrogen stimulation eventually causes cystic or adenomatous endometrial hyperplasia. The latter is a premalignant lesion that undergoes malignant degeneration in approximately 25% of cases. The causative relationship between estrogen and endometrial hyperplasia is well established; there is some indication but no proof that estrogen also provokes the change from hyperplasia to neoplasia and malignancy. Endometrial hyperplasia often results in abnormal uterine bleeding. Such bleeding, particularly in older women, constitutes an indication for biopsy or curettage of the endometrium to establish histopathologic diagnosis and to rule out malignancy. A functioning estrogen-secreting tumor is suspected if the woman is not taking estrogen medication. Progestogen therapy is effective in reversing the abnormal histopathologic changes of endometrial hyperplasia. If hyperplasia is adenomatous, hysterectomy is commonly performed.
Mosby's Medical Dictionary, 8th edition. © 2009, Elsevier.

endometrial hyperplasia
Adenomatous hyperplasia of endometrium Gynecology A premalignant endometrial lesion of older ♀
Endometrial hyperplasia
Hyperplasia without atypia Glands are crowded w/o cytologic atypia; these have a < 2% progress to carcinoma
Simple hyperplasia Glands are not back-to-back
Complex hyperplasia Glands are back-to-back
Hyperplasia with atypia Glands are crowded with cytologic atypia; ± 23% progress to carcinoma

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

endometrial hyperplasia
increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
Farlex Partner Medical Dictionary © Farlex 2012

en·do·me·tri·al hy·per·pla·si·a (en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.

Link to this page:

Please bookmark with social media, your votes are noticed and appreciated:

?Page tools
Printer friendly
Cite / link
Add definition
?My Word List
Add current page to the list
Feed a hungry child - donate to school feeding program
Mentioned in?  References in periodicals archive?   Medical browser?   Full browser?
We prefer the following designations: * epithelial hyperplasia; * epithelial hyperplasia with keratosis; * epithelial hyperplasia with atypia (slight, moderate, or severe); * carcinoma in situ (focal or diffuse); and * squamous cell carcinoma (superficial invasion or invasive).
Regarding flat epithelial atypia, although 4 of 5 columnar cell hyperplasia with atypia showed changes with recurrent losses on 16q (2 of 5) and 18p (2 of 5), 3 of 5 columnar cell changes with atypia revealed chromosomal aberrations with recurrent losses on 16q and 17p (both 2 of 5 cases).
Significantly decreased P27 expression in endometrial carcinoma compared to complex hyperplasia with atypia (correlation with p53 expression).
Medical Dictionary

Mobile Site | Terms of Use | Privacy policy | Feedback | Advertise with Us | Copyright © 2013 Farlex, Inc.
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.